Fluctuating macroinvertebrate populations suggest that climate, land‐use changes and habitat conversion drive global stream health trends. Although management practices (MPs) are widely implemented to mitigate in‐stream habitat degradation, our synthesis of macroinvertebrate metrics in agricultural and urban streams revealed inconsistent outcomes (43% positive, 19% negative, 38% neutral), varying by region, land use, MP type and metric measured (Sabat‐Bonilla et al., in prep.). For example, in the Valley and Ridge, functional metrics were the strongest indicators of positive MP effects, whereas structural metrics were less responsive, and biotic indices often remained unchanged. In the Coastal Plain, only functional metrics responded to MPs, being negative. In this study, we compare structural metrics (e.g., macroinvertebrate density) and functional metrics (e.g., biomass) relative to the regional Index of Biotic Integrity (Chessie B‑IBI) along gradients of agricultural disturbance and MP implementation. Preliminary findings in the Valley & Ridge indicate that low‐pasture streams with extensive MP coverage support higher taxon richness (~53 taxa) but exhibit lower total biomass (3,705 mg/m²) and density (20,557 indiv./m²). In contrast, high-pasture catchments with low‐to‐medium MP coverage harbor fewer sensitive taxa (43–46 taxa) yet display substantially greater biomass (13,500 mg/m²) and density (128,073 indiv./m²). Indicator‐species analyses reveal that sensitive taxa (e.g., Epeorus, Micrasema, Leuctridae) strongly correlate with enhanced MP coverage, while tolerant taxa dominate in heavily pastured catchments. Our ongoing work will extend this analysis to Coastal Plain streams to assess how region, agricultural intensity and MP implementation shape both structural and functional responses.